Define the populations
Identify malignant, stromal, immune or other supporting cells and the relationship the experiment needs to preserve.
Application pathway: cancer models
Design the model around the microenvironment.
Cancer biology is shaped by malignant cells, supporting populations, extracellular matrix and spatial interactions. JetBio explores where controlled placement and high-cell-density gel workflows can add experimental value.
Start with the disease question
Which interaction must the model reproduce?
A useful model does not attempt to recreate every feature of a tumour or bone-marrow niche. It includes the cells, matrix and organisation needed to investigate a specific mechanism or response.
Specify the material context
Select hydrogel components, stiffness, crosslinking and any biochemical cues against the hypothesis.
Plan the architecture
Decide where density, distance, boundaries or neighbouring regions may affect the intended readout.
Potential workflow value
Create structure that serves the assay.
JetBio can assess whether ReJI, microvalve or inkjet development modes could place the required cells and materials within the intended culture format. Model quality must then be judged with the biological assay, not from print appearance alone.
- High-cell-density gel regions
- Selected co-culture arrangements
- Defined plate or substrate formats
- Controls and treatment comparisons
- Imaging and downstream sampling access
Feasibility brief
Specify what would make the model useful.
What is the biological hypothesis?
State the interaction, mechanism or response the model should help investigate.
What is the current limitation?
Describe where 2D culture, spheroids, organoids, matrices or another printer fall short.
Which endpoint matters?
Define the assay, sampling points, instrumentation and expected control response.
What must be repeatable?
Set practical criteria for deposition, culture, biological response and replicate performance.
Evidence boundary
Development pathway, not a validated outcome claim.
JetBio has supported research activity in cancer and 3D in vitro model development, including an NC3Rs-backed workshop and a doctoral programme covering ReJI in vitro models. The suitability of any specific cancer model requires application-level evidence.
NC3Rs cancer disease-modelling workshopReactive jet impingement for in vitro model development thesis
Research activity and workshops are not evidence of a commercially validated assay, customer sale or regulatory acceptance.
Choose your next step
Follow the journey that matches the decision.
Academic and institute teams
Assess model design, experimental fit, research evidence and the feasibility route.
Visit the researcher journeyPharma, biotech and CRO teams
Connect the model to a defined drug-development use, performance threshold and adoption pathway.
Visit the drug-discovery journeyStart a useful conversation
Define the cancer model you need.
Share the cells, matrix, architecture, assay and evidence threshold. JetBio will assess whether modular bioprinting offers a credible route.